HPLC Guard Column
— Extend Your Column Lifetime 3–10x
✔ Compatible with Agilent / Waters / Shimadzu
✔ OEM / Custom / Fast Delivery
✔ Free Cartridge Selection Guide
GET Quotation Now
Why Do You Need an HPLC Guard Column?
A Guard Column is a low-cost insurance that protects your main analytical column and keeps your chromatographic system running longer and more reliably.
- Irreversible damage from dirty samples
- Column contamination decreases column efficiency
- Time lost due to system instability
- Expensive main column replacement
Key Benefits:
1.Extended Column Lifespan:
Increases the durability and utility of your columns.
2.Consistent Performance:
Maintains integrity of chromatographic results.
3.Cost-Effective:
Reduces the need for replacements, saving time and money.
4.Versatile Compatibility:
Works with major columns such as Agilent, Waters, Phenomenex.
5.Easy Integration:
Simple installation meeting unique lab requirements.
Direction Guard Column
Standard Guard Column
Guard Cartridges
Preparation Guard Column
① Analytical HPLC Guard Column
Item: P3K0B00272
1.Cartridge Size Option:
5μ / 3μ / 2μ / 1.8μ
2.Cartridge Option:
Reversed Phase / HILIC
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
Item: P3K0B-00148
1.Cartridge Size Option:
5μ / 3μ / 2μ / 1.8μ
2.Cartridge Option:
Reversed Phase / HILIC /Normal Phase/SEC
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
Item: P3K0B-00275 ( SS )
Item: P3K0B-00099 ( peek)
1.Cartridge Size Option:
5μ / 3μ / 2μ / 1.8μ
2.Cartridge Option:
Reversed Phase / HILIC /Normal Phase/SEC
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
Item: P3K0B-00280
1.Cartridge Size Option:
5μ / 3μ / 2μ / 1.8μ
2.Cartridge Option:
Reversed Phase / HILIC /Normal Phase/SEC
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
Item: P3K0B-00148
1.Cartridge Size Option:
5μ / 3μ
2.Cartridge Option:
Reversed Phase / HILIC / Normal Phase / SEC
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
Item: P3K0B-00075
1.Cartridge Size Option:
5μ / 3μ / 3.5μ
2.Cartridge Option:
Reversed Phase / HILIC / Normal Phase / SEC
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
② Preparative HPLC Guard Column
Item: P3K0B-00209
1.Cartridge Size Option:
10μ / 5μ
2.Cartridge Option:
General Type C18 / Pure Water-resistant C18
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
Item: P3K0B-00060
1.Cartridge Size Option:
10μ / 5μ
2.Cartridge Option:
General Type C18 / Pure Water-resistant C18
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
Item: P3K0B-00265
1.Cartridge Size Option:
10μ / 5μ
2.Cartridge Option:
General Type C18 / Pure Water-resistant C18
Choose guard cartridges with
C18, C8, Phenyl, Bio-SEC, or
HILIC-SiO2 to enhance your
analytical results.
③ HPLC Guard Cartridges
2.1 UHPLC Cartridge Stainless Steel Super High Pressure
2.1 Peek UHPLC Cartridge for Analytical Guard Cartridges
Peek 3.0 HPLC Cartridge for Analytical Guard Cartridges
4.6 Peek HPLC Cartridge, HPLC Column Assembly for sale
4.6 Peek HPLC Cartridge with Stainless Steel Frit
10.0 Peek HPLC Cartridge with Stainless Steel Frit
21.2 Stainless Steel HPLC Cartridge for Prep HPLC Guard Column
30.0 Stainless Steel HPLC Cartridge for for Prep HPLC Guard Column
Why Buy HPLC Guard Column from uHPLCs
than Waters, Phenomenex and Agilent
Innovative design to help Compatible Most of HPLC Fittings
Installing the uHPLCs Guard Protection System is seamless and efficient:
- Easy Installation: Simply attach to your preferred column; no complex setup required.
- Floating Outlet Design: Automatically adjusts to match the precise depth of columns from nearly any manufacturer.
- Low Dead Volume: Optimizes performance by minimizing dead volume.
- Leak-Free Connection: Ensures a secure, leak-free seal without the need for unions or adapters.
- Universal Compatibility: Suitable for use with columns from various manufacturers, ensuring versatility across different systems.
Top Hardware HPLC,UHPLC Consumables Supplier
Work with 100+ Brands & University
SERVICES
Customization
We can customize the design and specification of guard columns based on the specific requirements of the OEM.
Private labeling
We offer private labeling solutions for OEM guard columns, which includes the OEM's branding, logo, and labeling.
Quality control
We review every aspect of the production process for excellence and consistently deliver exceptional results.
Technical support
We provide technical support for OEM guard columns with expert assistance on troubleshooting, maintenance, and training.
WHY US
uHPLCs manufactures high-quality HPLC guard columns designed to protect analytical and semi-preparative columns.
1. Our columns have properties like low dead volume, high peak capacity, and excellent retention stability. With their expertise in analytical chemistry and commitment to innovation and customer satisfaction, uHPLCs has become one of the leading HPLC guard column manufacturers.
2. Achieve Better Chromatographic Separation, accuracy, and reproducibility in your analyses with uHPLCs guard columns.
CLIENT TESTIMONIALS
I have been purchasing guard columns from uHPLCs for years and could not be happier with their quality and performance. The guard columns have protected my analytical columns from contamination and increased their lifespan, ultimately saving me time and money in the long run.
Maria Rodriguez
Thanks to uHPLCs' customizable guard column options, we were able to find the perfect fit for our unique HPLC system. Their technical support team was also extremely helpful in guiding us through the process and ensuring we had the best product for our needs.
William Hayes
We recently started using uHPLCs' private labeling service for our guard columns and have been impressed with the resulting brand recognition and customer loyalty. The quality control and assurance measures taken by uHPLCs have also given us peace of mind in knowing that our clients are receiving a reliable and consistent product
Samantha Lee
1.What exactly does a HPLC guard column protect against?
A HPLC guard column traps particulates, sample impurities, matrix residues, and strongly retained compounds before they reach the analytical column. This prevents contamination, pressure increases, and peak shape deterioration — which helps extend column lifetime.
2. Will a guard column affect my peak shape or separation?
No — our guard columns are designed with low dead volume to maintain stable peak shape and consistent chromatographic performance. If properly matched to your analytical column, there is no negative impact on resolution.
3. How do I choose the right guard column?
Match these parameters to your analytical column:
Same stationary phase (e.g., C18 / C8 / CN / Phenyl)
Same or smaller particle size (3 μm / 5 μm)
Same column ID (2.1 / 3.0 / 4.0 / 4.6 mm)
If you’re unsure, send us your main column model and we will recommend the correct guard column.
4. Is the guard column compatible with my HPLC system?
Yes — our guard columns are compatible with Agilent, Waters, Thermo, Shimadzu, and most standard HPLC fittings. Custom adapters are available if needed.
5. How long does a guard column usually last?
Lifetime depends on sample cleanliness and application, but customers typically see a 3–10x longer analytical column life. When backpressure rises or peak shape degrades, the guard cartridge should be replaced.
6. Can I replace only the cartridge, or do I need a whole new guard column each time?
You can replace only the guard cartridge — the holder can be reused many times. This keeps long-term consumable cost very low.
7. Do you offer custom dimensions or packing materials?
Yes — we support OEM/ODM for:
✔ Special lengths / IDs
✔ Custom stationary phases
✔ High-temperature or corrosive media applications
8. Do guard columns work for UHPLC as well?
Yes — UHPLC cartridges with smaller particle sizes are available. Just specify your main column model or application.
9. How fast can you deliver?
Standard sizes are in stock for fast delivery. Customized specifications can be produced upon request.