HPLC Frits for HPLC & UHPLC Columns
Precision 316L stainless steel and PEEK frits for analytical, UHPLC, semi-preparative and preparative chromatography columns. Standard replacement sizes and custom OEM frits are available.
uHPLCs manufactures sintered HPLC frits used at column inlets and outlets and in inline filter housings. Choose by column ID, material and pore size, or send a drawing, sample or existing part number for a replacement match.
316L Stainless Steel & PEEK
0.2–20 μm standard pores
2.1–50 mm column sizes
Analytical to preparative HPLC
Custom OEM available
Find the Right HPLC Frit
Select by column size, material, pore size or application. Each option jumps to the matching section on this page.
Material
Application
UHPLC · Analytical HPLC · Semi-Preparative HPLC · Preparative HPLC · Inline Filtration
HPLC Frit Types
The current product range covers sintered disc frits, column cap frits and inline-filter elements in 316L stainless steel and PEEK. Request a quote with column ID, pore size and material.
Stainless Steel HPLC Frits
316L stainless steel frits for high-pressure analytical, UHPLC and preparative chromatography applications.
PEEK HPLC Frits
Metal-free frit solutions for bioinert and metal-sensitive chromatography applications.
HPLC Column Cap Frits
Precision inlet and outlet frit assemblies for analytical HPLC columns in 2.1, 3.0, 4.0 and 4.6 mm sizes.
Preparative HPLC Frits
Large-diameter frits for semi-preparative and preparative chromatography columns, including 10, 20, 30 and 50 mm sizes and DAC filters.
HPLC Inline Filter Frits
Replaceable sintered disc elements with PEEK or PCTFE sealing rings for protecting HPLC flow paths and analytical columns.
HPLC Frit Specifications
The options below are taken from the current uHPLCs HPLC frit product list. Custom diameter, thickness, pore size and seal geometry are quoted from drawing or sample.
| Parameter | Available options on this product line |
|---|---|
| Material | 316L stainless steel / PEEK. Inline discs also offered with PEEK or PCTFE sealing rings. |
| Pore size | Standard sintered range 0.2 / 0.5 / 2 / 5 / 10 / 20 μm. 4.0–50 mm PEEK parts also list 15 μm. DAC stainless steel filters additionally list 30 μm and 40 μm. OEM pore size on request. |
| Column / frit size | 2.1 / 3.0 / 4.0 / 4.6 / 10 / 20 / 30 / 50 mm, plus custom. |
| Inline disc dimensions | OD 6.4 / 6.5 / 14.4 / 19.1 / 22.4 / 38.0 mm; ID 1.6 / 2.4 / 3.2 / 12.0 / 15.8 / 19.0 / 33.0 mm; thickness 1.6 / 2.0 mm. |
| Configuration | Disc frit / cap frit / sealed PEEK cap frit / inline filter frit / DAC column filter |
| Application | UHPLC / analytical HPLC / semi-preparative / preparative / inline filtration |
| Customization | Diameter, thickness, pore size, structure and seal. Drawing- or sample-based OEM. |
Maximum pressure depends on frit diameter, thickness, material and the column hardware around it. Send the column model or drawing if a pressure rating is required for qualification.
HPLC Frits by Column Size
Inline-filter replacement discs are listed first, with catalog SKUs. The 2.1–50 mm groups after that are HPLC column cap frits and disc frits for column hardware — a different part family.
HPLC Inline Filter Frits
These SKUs are replacement sintered discs for HPLC inline filter holders. P4K0B codes are complete assemblies; P5F0B / P5F0F / P5F0P / H02K codes are the replaceable frits. They are not HPLC column cap frits. Also listed on HPLC inline filter frits.
PEEK frit for HPLC inline filter
Sintered metal disc with PEEK sealing ring. Replacement SKUs by size are in the table below.
PCTFE frit for HPLC inline filter
Sintered metal disc with PCTFE sealing ring. Replacement SKUs by size are in the table below.
| Size | Type | Fits holder | Replacement frits | Material |
|---|---|---|---|---|
| 2.1 mm | Direct-connect UHPLC / UHPLC | P4K0B-00268P4K0B-00105 | 0.2 μm — P5F0B-001600.5 μm — P5F0B-001622 μm — P5F0B-00161 | 316L stainless steel |
| 3.0 mm | Direct-connect HPLC / HPLC | P4K0B-00269P4K0B-00262 | 0.2 μm — P5F0F-002720.5 μm — P5F0F-002732 μm — P5F0F-00274 | 316L stainless steel / PEEK |
| 4.6 mm | HPLC SS / PEEK holders | P4K0B-00019P4K0B-00190 | 0.2 μm — P5F0F-002890.5 μm — P5F0F-000352 μm — P5F0F-000455 μm — P5F0F-0029310 μm — P5F0F-0007220 μm — P5F0F-00282 | 316L stainless steel / PEEK |
| 10 mm | Semi-preparative | P4K0B-00030 | 0.5 μm — P5F0P-000732 μm — P5F0P-000475 μm — P5F0P-00029410 μm — P5F0P-0003315 μm — P5F0P-00261 | 316L stainless steel / PEEK |
| 20 mm | Preparative | P4K0B-00029 | 0.5 μm — P5F0P-001032 μm — P5F0P-000415 μm — P5F0P-0026610 μm — P5F0P-00032 | 316L stainless steel / PEEK |
| 30 mm | Preparative | P4K0B-00200 | 0.5 μm — P5F0P-0002642 μm — P5F0P-0000495 μm — P5F0P-00019910 μm — P5F0P-000296 | 316L stainless steel / PEEK |
| 50 mm | Preparative | P4K0B-00271 | 3.5 μm — H02K-021325 μm — H02K-0156210 μm — H02K-0156320 μm — H02K-01564 | 316L stainless steel / PEEK |
Replacement frits sold separately have a minimum order of 10 pieces. Complete holders are quoted on the HPLC inline filter page.
The sizes below are HPLC column cap frits and disc frits for column hardware. They are not the inline-filter replacement discs listed above.
2.1 mm HPLC Column Cap Frits
316L stainless steel for UHPLC: 0.2 μm, 0.5 μm, 2 μm. PEEK option: 2 μm.
3.0 mm HPLC Column Cap Frits
316L stainless steel for UHPLC: 0.2 μm, 0.5 μm, 2 μm. PEEK option: 2 μm.
4.0 mm HPLC Column Cap Frits
PEEK big-hole options: 0.5 / 2 / 5 / 10 / 15 / 20 μm.
4.6 mm HPLC Column Cap Frits
Materials: 316L stainless steel and PEEK. Pore size 0.5 / 2 / 5 / 10 / 15 / 20 μm.
10 mm Semi-Preparative Frits
PEEK frit / PEEK filter: 0.5 / 2 / 5 / 10 / 15 / 20 μm. Big-hole design listed to 15 μm on the 10 mm cap frit.
20 mm Preparative Frits
PEEK frit and PEEK cap frit. Pore size 0.5 / 2 / 5 / 10 / 15 / 20 μm.
20 mm PEEK frit
Semi-prep / prep disc frit.
30 mm Preparative Frits
PEEK frit and PEEK cap frit. Pore size 0.5 / 2 / 5 / 10 / 15 / 20 μm.
30 mm PEEK frit
Preparative HPLC disc frit.
50 mm Preparative Frits
PEEK frit and PEEK cap frit for preparative HPLC. Pore size 0.5 / 2 / 5 / 10 / 15 / 20 μm.
50 mm PEEK frit
Preparative disc frit.
DAC HPLC Column Filter
316L stainless steel. Pore size 0.5 / 2 / 5 / 10 / 15 / 20 / 30 / 40 μm. OEM pore size available.
DAC stainless steel HPLC filter
Dynamic axial compression column filter. OEM pore size on request.
How to Choose HPLC Frit Pore Size
Frit pore size should retain packing particles while keeping pressure drop and clogging risk under control. A pore that is too open lets fines migrate; a pore that is too tight raises backpressure and clogs sooner. Match the frit to the column ID and the packing you actually use, then confirm solvent and hardware limits.
The ranges below are the selection bands already published on this product line. They are starting points, not a substitute for the packing-particle data on your column certificate.
| Typical application | Typical frit pore size on this product line |
|---|---|
| UHPLC / very fine packing | 0.2–0.5 μm (listed on 2.1 mm and 3.0 mm 316L UHPLC frits) |
| Analytical HPLC columns | 2 μm is the most commonly listed analytical pore; 4.6 mm parts also list 0.5–20 μm |
| Semi-preparative columns | 5–20 μm, as listed for 10–20 mm PEEK frits |
| Preparative / DAC filters | 10–40 μm; DAC stainless steel filters list up to 40 μm |
Consult our chromatography specialist for application-specific recommendations. If you have packing particle size, column ID and an existing part number, send them with the RFQ.
Read the full HPLC frit selection guide → Choosing the Best HPLC Frit.
PEEK vs Stainless Steel HPLC Frits
Material choice follows sample chemistry and operating pressure. The comparison uses the material notes already on this page. Pressure capability is configuration dependent and is not listed as a single catalog value here.
| 316L stainless steel | PEEK | |
|---|---|---|
| Material | 316L sintered stainless steel | PEEK (polyether ether ketone) |
| Pressure resistance | Used on this line for high-pressure HPLC/UHPLC; exact rating is configuration dependent | Configuration dependent; selected for bioinert and metal-sensitive work rather than a published psi rating |
| Metal-free flow path | No | Yes — no metal-ion leaching noted for biomolecule and ion-exchange use |
| Chemical resistance | Used with organic mobile phases on the current selection guide | Used with high-water / acidic systems and metal-sensitive samples |
| Bioanalysis | General HPLC use | Preferred when a metal-free path is required |
| UHPLC suitability | 2.1 / 3.0 mm 316L parts list 0.2 / 0.5 / 2 μm UHPLC pores | 2.1 / 3.0 mm PEEK option listed at 2 μm |
| Typical applications | High-pressure analytical, UHPLC, DAC and preparative metal frits | Bioinert columns, ion-exchange, PEEK cap/seal frits, inline discs with polymer seals |
| Custom sizes | Yes — diameter, thickness, pore size, structure | Yes — including sealed cap frits |
Replacement HPLC Frits & Compatibility
uHPLCs supplies replacement and custom frit solutions for a wide range of HPLC and UHPLC column configurations. Frits are offered as compatible replacement options designed to fit common column IDs and hardware styles used with Agilent, Waters, Shimadzu and Thermo Fisher Scientific systems. This is not an authorized or official spare-parts program for those brands.
Have an existing part number? Send the OEM part number, column model, frit dimensions, drawing, existing sample and required quantity.
Custom & OEM HPLC Frit Manufacturing
uHPLCs is an OEM supplier of HPLC column frits. The factory quotes from drawings, samples and existing part numbers for both prototype evaluation and batch production.
- Custom diameter, thickness and pore size
- 316L stainless steel and PEEK configurations
- Cap frit structures and sealed PEEK cap assemblies
- Inline discs with PEEK or PCTFE sealing rings
- DAC column filters with OEM pore size
- Drawing-based manufacturing and sample replication
Send us your drawing, sample, dimensions or existing part number for evaluation.
Quality Control for HPLC Frits
HPLC frits are produced with the same column-hardware workflow shown on the current page: dimensional control, inspection before packaging, and application testing of packed hardware. Named bubble-point or flow-test certificates are issued when they are part of the agreed OEM specification — ask for the inspection items you need on the RFQ.
Dimensional inspection before packaging
Packed-column analytical check
Column hardware manufacturing
How to Select the Right HPLC Frit
Use this sequence when specifying a replacement or OEM HPLC frit. Keep the answer to the hardware in front of you: column ID, packing, solvents and the old frit if you still have it.
- Confirm column ID. 2.1 mm columns take 2.1 mm frits; 4.6 mm columns take 4.6 mm frits. Semi-prep and prep follow 10 / 20 / 30 / 50 mm. The current selection table also lists 7.8 mm where that hardware is used.
- Confirm packing particle size. The frit must retain the bed. If the certificate is missing, send a sample frit or the column model.
- Select pore size. 0.2–0.5 μm for UHPLC / very fine packing; 2 μm is the usual analytical listing; 5–20 μm for semi-prep; 10–40 μm for prep and DAC filters.
- Choose stainless steel or PEEK. High-pressure HPLC/UHPLC and organic mobile phases typically use 316L. Metal-sensitive, biomolecule or high-water / acidic methods typically use PEEK.
- Check chemical compatibility of both the frit and any PEEK or PCTFE seal with the mobile phase.
- Confirm configuration: disc frit, cap frit, sealed cap, inline disc or DAC filter.
- Confirm replacement dimensions (OD, ID, thickness) when swapping an existing part. Inline discs on this line list OD, ID and 1.6 / 2.0 mm thickness.
Need help selecting? Send your column model or frit dimensions to the technical team via Contact Us. Related hardware: HPLC columns, empty chromatography columns and HPLC inline filters.
HPLC Frit FAQ
What is an HPLC frit?
An HPLC frit is a porous disc at the inlet and/or outlet of a chromatography column. It retains packing particles, spreads flow and keeps debris out of the bed. A short definition is also on What is a frit on a chromatography column?
What pore size should I use for an HPLC column?
On this product line, 2.1/3.0 mm UHPLC stainless steel frits list 0.2 / 0.5 / 2 μm. Analytical 4.6 mm parts list 0.5–20 μm, with 2 μm called out as the most common analytical pore. Semi-prep and prep PEEK frits list 0.5–20 μm; DAC filters list up to 40 μm. Confirm against your packing particle size.
What is the difference between PEEK and stainless steel HPLC frits?
316L stainless steel is used for high-pressure HPLC/UHPLC. PEEK is used when a metal-free path is required, including biomolecule and ion-exchange work. Pressure rating depends on the finished part, not the material name alone.
Can HPLC frits be replaced?
Yes. Replacement is a standard service when you can supply the column model, frit dimensions, drawing or a sample. Compatible options are offered for common Agilent, Waters, Shimadzu and Thermo Fisher column IDs; that does not mean authorized OEM spare parts for those brands.
What causes HPLC frit clogging?
Particulates from samples, mobile phase, worn seals or bed collapse collect on the inlet frit and raise backpressure. Prevention and cleaning are covered in Why HPLC Frits Clog and clogged HPLC systems.
Can uHPLCs manufacture custom frit sizes?
Yes. Custom diameter, thickness, pore size, cap/seal structure and inline disc OD/ID are quoted from drawing or sample, including prototype and batch production.
What information is needed for a custom HPLC frit?
Send column ID, pore size, material, configuration (disc, cap, inline, DAC), OD/ID/thickness if known, quantity, and either a drawing, sample or existing part number.
How do I find a replacement frit for an existing HPLC column?
Start with column ID and the old frit dimensions. If the part number is still on the bag or hardware, send it with a photo. We match a catalog size or cut an OEM equivalent.
HPLC Frit Technical Guides
Use these articles for informational detail. This page remains the commercial hub for HPLC frits, replacement frits and OEM column frits.
What is a frit on a chromatography column?
Definition of the inlet/outlet frit and how it retains packing in an HPLC column.
Why HPLC frits clog
Common sources of inlet-frit blockage and what to check when backpressure rises.
Choosing the best HPLC frit
Selection factors for pore size, material and column compatibility.
HPLC column frit choosing
Practical notes on matching frit geometry to column hardware.
Three essential HPLC filters
Where column frits sit next to solvent inlet filters and inline filters.
Clogged systems in HPLC
Broader troubleshooting when frits, tubing or the column bed are involved.
Need a Standard or Custom HPLC Frit?
Tell us your column size, pore size, material, existing part number or application requirements. The chromatography team will help identify a suitable frit solution.
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