HPLC Inline Filter for HPLC & UHPLC
Trap particulates in the high-pressure flow path before they reach the injector or analytical column. HIPSOUL HPLC inline filters are available in 2.1–50 mm sizes, stainless steel and PEEK, with replaceable frits and OEM hardware.
An inline filter is a particle trap, not a packed guard column and not a reservoir solvent inlet filter. Choose by column ID, connection style and frit pore size, or send an existing part number for a match.
2.1–50 mm sizes
Direct-connect & standard
316L & PEEK options
Replaceable frits
OEM available
What Is an HPLC Inline Filter?
An HPLC inline filter is a high-pressure particle filter installed in the liquid chromatograph flow path. It captures debris from the pump, mixer, tubing or sample path so those particles do not reach the analytical column or detector. Typical frits are sintered metal or PEEK discs held in a stainless steel or PEEK housing.
It does not replace a solvent inlet filter in the reservoir, and it is not a packed guard cartridge. An inline filter is for particulates. A guard column also retains strongly retained sample components. Many HPLC systems use both.
- Trap particulates in the high-pressure flow path
- Protect the analytical column from debris
- Support replaceable frit service
- Cover analytical, UHPLC, semi-prep and prep sizes
How an HPLC Inline Filter Works
The filter body holds a porous frit across the flow path. Liquid passes; particles above the frit rating are retained. When backpressure rises, the frit is replaced rather than the entire housing on serviceable designs.
- Mobile Phase
- Pump
- Inline Filter
- Injector
- Analytical Column
- Detector
Typical high-pressure inline placement: after the pump and before the injector. Direct-connect models sit immediately ahead of the column. Follow the instructions for the specific configuration.
HPLC Inline Filter Options
Analytical sizes are also grouped on the analytical HPLC inline filter page. UHPLC 2.1 mm hardware is listed under UPLC in-line filters. Semi-prep and prep holders are listed under semi-prep HPLC precolumn filters. Replacement discs are on frits for HPLC inline filters and the HPLC frits hub.
Analytical & UHPLC Inline Filters
2.1 Direct Connect HPLC Inline Filter
Model P4K0B-00268
Size: 2.1 mm
Type: Direct-connect UHPLC
Material: 316L stainless steel
Frits: 0.2 μm (P5F0B-00160); 0.5 μm (P5F0B-00162); 2 μm (P5F0B-00161)
2.1 Ultra-High-Pressure HPLC Inline Filter
Model P4K0B-00105
Size: 2.1 mm
Type: UHPLC / high-pressure
Material: 316L stainless steel
Frits: 0.2 μm (P5F0B-00160); 0.5 μm (P5F0B-00162); 2 μm (P5F0B-00161)
3.0 High-Pressure Direct-Connect Inline Filter
Model P4K0B-00269
Size: 3.0 mm
Type: Direct-connect HPLC
Material: 316L stainless steel ferrule; 316L + PEEK frits
Frits: 0.2 μm (P5F0F-00272); 0.5 μm (P5F0F-00273); 2 μm (P5F0F-00274)
3.0 mm HPLC Inline Filter
Model P4K0B-00262
Size: 3.0 mm
Type: Standard HPLC
Material: 316L stainless steel ferrule; 316L + PEEK frits
Frits: 0.2 μm (P5F0F-00272); 0.5 μm (P5F0F-00273); 2 μm (P5F0F-00274)
4.6 mm Stainless Steel HPLC Inline Filter
Model P4K0B-00019
Size: 4.6 mm
Type: Standard inline
Material: 316L stainless steel + PEEK
Frits: 0.2 μm (P5F0F-00289); 0.5 μm (P5F0F-00035); 2 μm (P5F0F-00045); 5 μm (P5F0F-00293); 10 μm (P5F0F-00072); 20 μm (P5F0F-00282)
4.6 mm PEEK HPLC Inline Filter
Model P4K0B-00190
Size: 4.6 mm
Type: PEEK inline
Material: PEEK ferrule; 316L + PEEK frits
Frits: 0.2 μm (P5F0F-00289); 0.5 μm (P5F0F-00035); 2 μm (P5F0F-00045); 5 μm (P5F0F-00293); 10 μm (P5F0F-00072); 20 μm (P5F0F-00282)
Semi-Prep & Prep Inline Filters
10 mm Semi-Prep HPLC Inline Filter
Model P4K0B-00030
Size: 10 mm
Type: Semi-preparative
Material: 316L stainless steel ferrule; 316L + PEEK frits
Frits: 0.5 μm (P5F0P-00073); 2 μm (P5F0P-00047); 5 μm (P5F0P-000294); 10 μm (P5F0P-00033); 15 μm (P5F0P-00261)
20 mm Prep HPLC Inline Filter
Model P4K0B-00029
Size: 20 mm
Type: Preparative holder
Material: 316L stainless steel ferrule; 316L + PEEK frits
Frits: 0.5 μm (P5F0P-00103); 2 μm (P5F0P-00041); 5 μm (P5F0P-00266); 10 μm (P5F0P-00032)
30 mm Prep HPLC Inline Filter
Model P4K0B-00200
Size: 30 mm
Type: Preparative holder
Material: 316L stainless steel ferrule; 316L + PEEK frits
Frits: 0.5 μm (P5F0P-000264); 2 μm (P5F0P-000049); 5 μm (P5F0P-000199); 10 μm (P5F0P-000296)
50 mm Prep HPLC Inline Filter
Model P4K0B-00271
Size: 50 mm
Type: Preparative holder
Material: 316L stainless steel ferrule; 316L + PEEK frits
Frits: 3.5 μm (H02K-02132); 5 μm (H02K-01562); 10 μm (H02K-01563); 20 μm (H02K-01564)
Model numbers above are the ferrule codes from the current inline-filter catalog. Complete one-piece assemblies (housing + frit) are coded to the application on request. Replacement frits are sold separately; the listed frit SKUs have a minimum order of 10 pieces.
HPLC Inline Filter Specifications
| Model | Description | Size | Type | Material | Frits | Request Quote |
|---|---|---|---|---|---|---|
| P4K0B-00268 | 2.1 Direct Connect HPLC Inline Filter | 2.1 mm | Direct-connect UHPLC | 316L stainless steel | 0.2 μm — P5F0B-00160 0.5 μm — P5F0B-00162 2 μm — P5F0B-00161 | Request Quote |
| P4K0B-00105 | 2.1 Ultra-High-Pressure HPLC Inline Filter | 2.1 mm | UHPLC / high-pressure | 316L stainless steel | 0.2 μm — P5F0B-00160 0.5 μm — P5F0B-00162 2 μm — P5F0B-00161 | Request Quote |
| P4K0B-00269 | 3.0 High-Pressure Direct-Connect Inline Filter | 3.0 mm | Direct-connect HPLC | 316L stainless steel ferrule; 316L + PEEK frits | 0.2 μm — P5F0F-00272 0.5 μm — P5F0F-00273 2 μm — P5F0F-00274 | Request Quote |
| P4K0B-00262 | 3.0 mm HPLC Inline Filter | 3.0 mm | Standard HPLC | 316L stainless steel ferrule; 316L + PEEK frits | 0.2 μm — P5F0F-00272 0.5 μm — P5F0F-00273 2 μm — P5F0F-00274 | Request Quote |
| P4K0B-00019 | 4.6 mm Stainless Steel HPLC Inline Filter | 4.6 mm | Standard inline | 316L stainless steel + PEEK | 0.2 μm — P5F0F-00289 0.5 μm — P5F0F-00035 2 μm — P5F0F-00045 5 μm — P5F0F-00293 10 μm — P5F0F-00072 20 μm — P5F0F-00282 | Request Quote |
| P4K0B-00190 | 4.6 mm PEEK HPLC Inline Filter | 4.6 mm | PEEK inline | PEEK ferrule; 316L + PEEK frits | 0.2 μm — P5F0F-00289 0.5 μm — P5F0F-00035 2 μm — P5F0F-00045 5 μm — P5F0F-00293 10 μm — P5F0F-00072 20 μm — P5F0F-00282 | Request Quote |
| P4K0B-00030 | 10 mm Semi-Prep HPLC Inline Filter | 10 mm | Semi-preparative | 316L stainless steel ferrule; 316L + PEEK frits | 0.5 μm — P5F0P-00073 2 μm — P5F0P-00047 5 μm — P5F0P-000294 10 μm — P5F0P-00033 15 μm — P5F0P-00261 | Request Quote |
| P4K0B-00029 | 20 mm Prep HPLC Inline Filter | 20 mm | Preparative holder | 316L stainless steel ferrule; 316L + PEEK frits | 0.5 μm — P5F0P-00103 2 μm — P5F0P-00041 5 μm — P5F0P-00266 10 μm — P5F0P-00032 | Request Quote |
| P4K0B-00200 | 30 mm Prep HPLC Inline Filter | 30 mm | Preparative holder | 316L stainless steel ferrule; 316L + PEEK frits | 0.5 μm — P5F0P-000264 2 μm — P5F0P-000049 5 μm — P5F0P-000199 10 μm — P5F0P-000296 | Request Quote |
| P4K0B-00271 | 50 mm Prep HPLC Inline Filter | 50 mm | Preparative holder | 316L stainless steel ferrule; 316L + PEEK frits | 3.5 μm — H02K-02132 5 μm — H02K-01562 10 μm — H02K-01563 20 μm — H02K-01564 | Request Quote |
Where Should an HPLC Inline Filter Be Installed?
A high-pressure inline filter is typically installed after the pump and before the injector, so debris generated in the solvent delivery path is trapped before injection. Direct-connect 2.1 mm and 3.0 mm models are designed to sit immediately in front of the analytical column.
A solvent inlet filter belongs in the reservoir, on the low-pressure suction line. Do not treat an inline filter as a bottle filter, and do not treat a bottle filter as column protection.
HPLC Inline Filter vs Guard Column vs Inlet Filter
| Feature | Inlet filter | Inline filter | Guard column |
|---|---|---|---|
| Location | Solvent reservoir / suction tubing | High-pressure path (pump–injector or before column) | After injector, before analytical column |
| Main job | Keep particles out of the pump | Trap system-generated particles | Protect packing from sample contaminants |
| Typical pores (site listing) | 2–20 μm | 0.2–20 μm depending on size | Packed cartridge, not a simple frit |
Read Guard Column vs In-Line Filter and three essential HPLC filters for the full filtration stack.
Applications for HPLC Inline Filters
- Analytical HPLC
- UHPLC / UPLC 2.1 mm methods, using the listed 2.1 mm hardware
- Pharmaceutical QC and method development
- Food, environmental and chemical analysis
- Semi-preparative and preparative LC (10–50 mm holders)
Custom & OEM HPLC Inline Filters
Custom ID, housing, direct-connect geometry, frit pore size and private-label hardware can be evaluated. Packing phases such as C18 are not inline-filter products; those belong on HPLC columns. See OEM & custom capabilities.
Quality Control for HPLC Inline Filters
HIPSOUL inline filters are manufactured as HPLC hardware. Factory inspection and chromatographic system testing are part of the column-hardware workflow. This page does not publish SKU-specific pressure certificates.
How to Select an HPLC Inline Filter
- Match the filter ID to the column ID (2.1, 3.0, 4.6, 10, 20, 30 or 50 mm)
- Choose direct-connect vs standard fittings
- Select stainless steel or PEEK for solvent compatibility
- Choose frit pore size from the listed options for that model
- Confirm operating pressure against the specific configuration
- Plan frit replacement before backpressure rises
HPLC Inline Filter FAQ
What is an HPLC inline filter?
A high-pressure particle filter in the HPLC flow path. It holds a porous frit that retains debris before the injector or analytical column. It is not a packed guard column and not a bottle inlet filter.
Where should an HPLC inline filter be installed?
Typically after the pump and before the injector. Direct-connect models are installed immediately before the column. Always follow the instructions for that housing.
What is the difference between an inline filter and a guard column?
An inline filter traps particles. A guard column is a short packed cartridge after the injector that also retains strongly retained sample components. They can be used together.
What is the difference between an inline filter and an inlet filter?
An HPLC inlet filter sits in the solvent reservoir on the suction line. An inline filter sits in the high-pressure path. Both are needed in a complete filtration stack.
Can I replace the frit instead of the whole filter?
Yes on the serviceable designs listed here. Replacement frit SKUs are listed with each model and on HPLC frits of inline filter. Pore size must match the original rating. Frits sold separately have a minimum order of 10 pieces.
Are these filters packed with C18?
No. The current catalog is hardware and frits. C18, C8 and related phases are HPLC column products, not inline-filter packings.
Can uHPLCs manufacture custom inline filters?
Yes. Send ID, connection, pressure, frit pore size and any drawing via the contact form.
HPLC Filtration Guides
Guard Column vs In-Line Filter
When to use a particle filter versus a packed guard cartridge.
Three Essential HPLC Filters
Inlet, inline and column-inlet filtration in one HPLC stack.
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Need an HPLC Inline Filter Quote?
Send us your column ID, connection type, frit pore size or existing part number. We’ll help match the right inline filter.
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