Revolutionary 2.1mm UHPLC Direct-Connect Guard Column Hardware

🧪 Typical Applications of the 2.1 mm UPLC Direct-Connection Guard Column

✅ General-Purpose C18 (L1)

• Detection of saponins, flavonoids, polyphenols

• Analysis of veterinary drug residues and hormones

• Testing traditional Chinese medicinal materials and herbal preparations

💧 100% Water-Compatible C18

• Separation of cephalosporin antibiotics

• Analysis of water-soluble vitamins (e.g., Vitamin B complex)

• Detection of small-molecule drugs like Pefloxacin mesylate and Cimetidine

• Pharmaceutical QC for injections and tablets (e.g., Rifaximin, Decitabine, Docetaxel)

🧬 100% Water-Compatible + Low pH C18

• Quantification of amino acid derivatives and acid-sensitive drugs

• Suitable for polar acids like p-Chlorophenylacetic acid and o-Methylsalicylic acid

• Used in impurity profiling and stability testing (e.g., Estriol, Nimodipine)

🧪 Wide-pH Tolerant C18 (pH 1–11)

• Effective for drugs requiring strong pH stability (e.g., Pantoprazole Sodium, Imipenem)

• Ideal for formulations prone to strong or irreversible adsorption

• Broad-range detection from acidic to alkaline drugs in complex samples

⚗️ General-Purpose C8 (L7)

• Targeting hydrophobic analytes with moderate retention

• Ideal for small peptides, immunosuppressants (e.g., Tacrolimus), and herbal mixtures

• Applied in the testing of OTC syrups and oral liquids (e.g., Licorice Oral Liquid)

🌿 Phenyl Phase (L11)

• Specialized for aromatic and π-π interaction compounds

• Analysis of botanical extracts and hormone analogs (e.g., Montelukast, Oxytetracycline)

🧫 Size Exclusion Chromatography (SEC – L33/L59)

• Molecular weight profiling of:

  • Monoclonal antibodies (mAbs)

  • Enzymes, nucleic acids, ADCs

  • Biopharmaceutical development samples

💧 HILIC – Hydrophilic Interaction Chromatography

• Retention of very polar, hydrophilic substances

• Analysis of substances poorly retained in standard reversed-phase LC

• Quantification of glutamine–alanyl–glutamine and other small polar molecules