Direct Connect or Normal Guard Column: Which Is Better?
Why Use Guard Column in HPLC System Guard Columns: Protecting Your HPLC Investment Guard columns
Preparative Guard Cartridge
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HPLC Preparative Guard Columns are an essential part of a High Performance Liquid Chromatography (HPLC) system.
It is designed to protect the main column of an HPLC system from sample and buffer contamination that could affect its performance and impair the quality of results. A guard column is placed before the main column and acts as a pre-filter to remove impurities and particulates that might otherwise clog the column or interfere with the accuracy of sample analysis.
Guard columns come in a variety of sizes and pore sizes, depending on the application and type of column used. Guard columns are especially important in preparative HPLC for purification and separation of compounds from complex mixtures. They help extend primary column life, minimize downtime for column cleaning and replacement, and ensure consistent and reliable results.
Overall, HPLC preparative guard columns are a valuable investment in any HPLC system, helping to maintain the integrity of sensitive samples and improving the overall performance and lifetime of the system.
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Main Features
Here are some properties of HPLC preparative guard columns:
1. Compatibility: HPLC Preparative Guard Columns are designed to be compatible with a wide variety of HPLC systems and column types. You can choose a guard column that fits your existing system and column.
2. Versatility: Guard columns are available in a variety of pore sizes, so you can choose one that meets your specific application requirements. You can use them for preparative and analytical HPLC, normal and reversed phase chromatography, and other techniques.
3. Durability: High-quality HPLC preparative guard columns are made of durable materials that can withstand harsh solvents and high flow rates. They are durable enough to protect the main columns of your HPLC system for longer.
4. Ease of use: The guard column is easy to install and remove, making maintenance of your HPLC system worry-free. They are also easy to replace when contaminated and require minimal downtime for routine maintenance.
5. Improved results: The guard column protects the main column from contamination and prolongs its life, providing consistent and reliable results. The guard column also ensures that only high quality purified samples reach the main column, improving the accuracy of the analysis.
6. Cost-effective: Investing in HPLC preparative guard columns extends the life of your HPLC system, saving you money in the long run.
By protecting the main column from contamination, you can avoid costly repairs or replacements and reduce downtime.
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What Clients Say
I have been using the HPLC Preparative Guard Cartridge from uHPLCs for a few months now and I am extremely impressed with the results. The cartridge has helped improve the efficiency of my preparative HPLC system and reduced the contamination that occurs during the sample run. It is easy to install and use, and has definitely extended the lifespan of my HPLC system. I would highly recommend this guard cartridge to others.
Amanda LeeCEO 
Using the HPLC Preparative Guard Cartridge from uHPLCs has been a game changer for me. Previously, I had been experiencing significant downtime due to system contamination but since using the guard cartridge, I have seen a considerable improvement in system performance and a reduction in downtime. The cartridge is easy to install and has helped save me both time and money.
Adam CheiseDesigner 
As a long time user of uHPLCs, I was excited to try their HPLC Preparative Guard Cartridge. After using it for a few weeks, I can confidently say that it has exceeded my expectations. The cartridge is easy to use and has improved the quality of my HPLC results. The guard cartridge is reasonably priced and provides great value. I highly recommend the HPLC Preparative Guard Cartridge from uHPLCs to anyone seeking to improve their HPLC system performance.
Floyd StallerCo-Founder 
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Looking to increase the efficiency and performance of your HPLC system? Try HPLC Preparative Guard Columns for uHPLC!
Our guard columns reduce contamination and extend the life of your HPLC system, saving you time and money.
Contact us today to learn more about our HPLC preparative guard columns and see how they can benefit your laboratory.
Don’t let pollution and downtime hold you back. Upgrade your HPLC system with uHPLC today!
High Quality HPLC Column 316L, 316 Stainless Steel Tube Materials
Design New HPLC Columns 100% As Clients Request
Make HPLC Column Samples And Test Before Mass Products.
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HPLC Applications in Pharmaceutical Industry
Here are three applications for HPLC preparative guard columns:
1. Medical application: Pharmaceutical companies rely on HPLC systems to develop and manufacture safe and effective drugs. However, these systems can be susceptible to contamination, which can affect drug quality and safety. HPLC Preparative Guard Columns help reduce contamination and extend the life of your HPLC system, ensuring accurate and consistent results in pharmaceutical testing and manufacturing. In addition, this guard column improves column protection, reduces the risk of equipment failure and optimizes workflow.
2. Environmental testing: Environmental testing laboratories analyze water, air and soil samples to measure the presence and concentration of pollutants. Contamination in HPLC systems can cloud results, making accurate data difficult or impossible. HPLC preparative guard columns help reduce contamination of environmental samples and improve the accuracy of test results. The enclosures are easy to install and require minimal maintenance, making them ideal for busy environmental testing laboratories.
3. Catering analysis: Food and beverage manufacturers use HPLC systems to detect contaminants such as pesticides and additives to ensure their products are safe to eat. However, HPLC systems can be sensitive to contamination, leading to equipment failure and inaccurate analyses. HPLC Preparative Guard Columns help reduce contamination and extend the life of your HPLC system, providing accurate and consistent results in food and beverage analysis. This guard column is also ideal for high-throughput laboratories and fast-paced production environments where downtime is not an option.
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Frequently Asked Questions
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A: The HPLC Preparative Guard Cartridge is an accessory that protects and prolongs the life of an HPLC column, by trapping particulate matter that may otherwise damage or obstruct the column.
A: The guard cartridge works by trapping particles and contaminants that would otherwise damage the HPLC column. It is installed between the pump and the analytical column, and acts as a barrier between the column and the sample.
A: An HPLC Preparative Guard Cartridge is important because it can help to protect the HPLC column from damage caused by particulate matter. This can result in longer column life, more accurate analyses, and more consistent results.
A: The frequency with which you should change the guard cartridge depends on several factors, including the type and volume of samples being analyzed, as well as the length of time the system has been running. Generally, it is recommended to replace the cartridge after every 12-24 hours of use.
A: Yes, the HPLC Preparative Guard Cartridge can be used with most HPLC systems, although you should always check the manufacturer’s guidelines to ensure compatibility.
A: Yes, the guard cartridge is easy to install – no tools are required, and the process can be completed quickly and easily. Most guard cartridges simply click into place between the pump and the analytical column.
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